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Request pdf malignant transformation of a chronic anorectal fistula up to date, only a small number of carcinomas arising from a chronic anorectal fistula have been described in medical. Case report a 72-year-old man with a 6-year history of discharging perianal sinus without crohns disease arrived at our institution. His past medical history included right introduction malignant transformation of a chronic perineal fistula is a rare entity in patients without crohns disease. Malignant transformation of perineal fistula in crohns disease has rarely been reported. The aim of this study is to define the patients characteristics and clinical presentation of this rare.   malignant transformation of perineal fistula in crohns disease has rarely been reported. The aim of this study is to define the patients characteristics and clinical presentation of this rare disease. Malignant melanomas of the anal region are a rare occurrence, accounting for only around 0. Diagnosis may be challenging, since perianal melanomas may be disguised as haemorrhoids and more rarely as fissures or perianal abscesses. Prognosis is generally very poor , with five-year survival rates ranging between 6. One possibility is malignant degeneration within a long-standing anal fistula and this, although uncommon, has been well reported. The histology of such cases tends to be either squamous or mucinous, with rosser first describing in 1931 the 3 basic criteria for definitional purposes which determine that a fistula has undergone malignant transformation 12. Objective malignant transformation of fistulas has been observed, particularly in perianal fistulas in crohns disease (cd) patients. The prevalence of adenocarcinoma in enterocutaneous fistulas and non-cd-related fistulas, however, is unknown. We investigated adenocarcinoma originating from perianal and enterocutaneous fistulas in both cd patients and non-cd patients from nine large, mostly. Malignant transformation has been reported in 15 patients with ordinary condylomata acuminata as well. Twenty giant condylomata acuminata have been previously reported, six of which (30 percent) went on to develop squamous-cell carcinoma. The authors report eight cases of giant condylomata acuminata with invasive squamous-cell carcinoma developing in four. Mucinous adenocarcinoma is a rare tumor that may be associated with longstanding perianal fistulas. Perianal fistula (pf) is a common entity in the proctology area. However, the development of a mucinous adenocarcinoma (ma) arising from chronic anal fistula is extremely rare. The relation between both entities was first described by rosser et al. In 1934, who reported seven cases of fistula that had undergone malignant transformation.

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